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KMID : 0606320040200010054
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Journal of Phamacetical Sciences Sookmyung Women s University
2004 Volume.20 No. 1 p.54 ~ p.60
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Iontophoretic transport of NADPH
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Lee Seung-Yeon
Oh Seaung-Youl
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Abstract
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Nicotinamide Adenine Dinucleotide phosphate (NADPH) has antioxidant effect in the body and thus decreases the symptoms of senility. The delivery of NADPH through skin is a formidable challenge due to its physical and chemical properties (such as rapid decomposition by oxidation, low partition coefficient in stratum corneum, high molecular weight and charge). The purpose of this work is to prepare a hydrogel patch system containing NADPH, and to study its in-vitro iontophoretic transport through hairless mouse skin. We have investigated two factors (concentration of NADPH and current density) that can affect the iontophoretic flux. The stability of NADPH in aqueous solution and the possible skin irritation by iontophoretic flux. The stability of NADPH in aqueous solution and the possible skin irritation by iontophoretic delivery of NADPH was also investigated. The results showed that, compared to passive flux, the total amount of NADPH transported increased by the application of cathodal current. Anodal flux was similar to passive flux. Flux increase was proportional to the concentration of NADPH in the donor solution and to the current density. Nearly 50% of NADPH degraded during the experimental period in aqueous solution. The results of primary irritatation test showed no erythema or edema after iontophorsis. These results suggest that therapeutic amount of NADPH can be delivered through skin using iontophoresis, without any development of erythema or edema.
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KEYWORD
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